All 114 actors in both CSI: Crime Scene Investigation and Two and a Half Men
114 actors have appeared in both CSI: Crime Scene Investigation and Two and a Half Men, across 599 episodes. The most-credited is Liz Vassey, Wendy Simms in CSI: Crime Scene Investigation and Michelle, Kate in Two and a Half Men.
| Actor | In CSI: Crime Scene Investigation | In Two and a Half Men | Eps | Eps |
|---|---|---|---|---|
| Liz Vassey | Wendy Simms | Michelle, Kate | 45 | 4 |
| April Bowlby | Kaitlin Rackish, Sally | Kandi, Kimber | 2 | 13 |
| Aisha Tyler | Mia Dickerson | Allison | 12 | 1 |
| Clark Duke | Frat Boy #1 | Barry | 1 | 8 |
| Jenny McCarthy | Courtney | Courtney | 1 | 8 |
| Rebecca McFarland | Jason Kent's Attorney | Leanne | 1 | 8 |
| Robert Wagner | Teddy | Teddy | 1 | 5 |
| D.B. Sweeney | Kyle Goode | Larry | 1 | 10 |
| Jodi Lyn O'Keefe | Kaye Shelton | Isabella, Gail | 1 | 4 |
| Katherine LaNasa | Ginger | Lydia | 1 | 4 |
| Kris Iyer | ER Surgeon | Dr. Prajneep | 1 | 4 |
| Deanna Russo | Lori Kyman | Laurel | 1 | 3 |
| Krista Allen | Kristy Hopkins | Olivia | 3 | 1 |
| Tricia Helfer | Ashleigh James | Gail | 1 | 3 |
| Wayne Wilderson | Paramedic Edwin Kelso | Dad, Roger | 6 | 2 |
| Kay Panabaker | Lindsey Willows | Sophie | 6 | 1 |
| Alicia Coppola | Dr. Susan Hillridge | Dr. Michelle Talmadge, TC Randall | 1 | 2 |
| Coby Ryan McLaughlin | Derk Barlow | Jeremy | 1 | 2 |
| Edie McClurg | Madge | Helen | 2 | 1 |
| Gail O'Grady | Lynn Towne | Mandi | 1 | 2 |
| Lee Garlington | Mrs. Briggs, Mrs. Frommer | Peggy | 2 | 1 |
| Paula Marshall | Ms. Kathy Veck | Paula | 1 | 2 |
| Steve Hytner | John Claddon | Dr. Schenkman | 1 | 2 |
| Steven Eckholdt | John Dudek | Brad Harlow | 1 | 2 |
| Vernée Watson | Manager | Nurse, Karen | 1 | 4 |
| Chloe Webb | Evelyn Polychronopolous | Trudy | 1 | 1 |
| Christina Chambers | Vicki Mercer | Kimberly | 1 | 1 |
| Cynthia Preston | Waitress | Heather | 1 | 1 |
| Juliette Goglia | Hannah West | Joanie | 2 | 2 |
| Kristin Dattilo | Paula Bonfilio | Cindy | 1 | 1 |
| Myndy Crist | Rebecca Brewer | Wendy | 1 | 1 |
| Andy Mackenzie | Badger, Teddy | Ronald Wiedermeier | 2 | 1 |
| Carrie Reichenbach | Alexis | Alexis | 1 | 2 |
| Gigi Rice | Terri Durbin, Yvette Baker | Christine | 2 | 1 |
| Jonathan Banks | Bobby Jensen | Sid | 2 | 1 |
| Judd Nelson | Mick Logan | Chris Mackelroy | 1 | 2 |
| Meagen Fay | Rochelle Dorley | Martha | 1 | 2 |
| Michael Patrick McGill | Ruben Caster | Joseph, Officer Smith | 1 | 2 |
| Sandra Purpuro | Shelley Stark | Cynthia, Mona | 1 | 2 |
| Tricia O'Kelley | Debbie Dunbar | Brooke, Shari | 1 | 2 |
| Tom Virtue | Doctor, George | Freddy The Minister, Stan | 2 | 2 |
| Alexis Krause | Rachel Walker | Kelly | 1 | 1 |
| Bre Blair | Tracy | Rachel | 2 | 1 |
| Brian George | Dr. Parayan | TV Narrator | 1 | 1 |
| Christopher Jacobs | Luke | Dave | 1 | 1 |
| David Starzyk | Congressman Griffin, Fred Stearns | Eric | 2 | 1 |
| Deprise Brescia | Purple | Vanessa | 1 | 1 |
| Eric Allan Kramer | Deputy Sheriff, Vic Patterson | Bill | 2 | 1 |
| Ernie Grunwald | Lester Martin | Clinician | 1 | 1 |
| Frances Fisher | Joanna Sapphire | Priscilla Honeycutt | 1 | 1 |
| Gary Anthony Williams | Police Impound Driver | Leo | 1 | 1 |
| Ion Overman | Female Reporter | Vicki | 1 | 1 |
| Jamie Luner | Elizabeth Rodriguez | Tracy | 1 | 1 |
| Jeanette O'Connor | Catty Woman | Debbie | 1 | 1 |
| Jenna Gering | Alison Scott | Naomi | 1 | 1 |
| Jessica Lu | Lily | Jean | 1 | 1 |
| Julia Campbell | Janet Marie Marsh | Francine | 1 | 1 |
| Lindsay Price | Ms. Marita | Whitney | 1 | 1 |
| Madison Mason | Vance Colton | Tommy Pearson | 1 | 1 |
| Mark Deklin | Ryan Miller | Marcus | 1 | 1 |
| Natalie Zea | Needra Fenway | Colleen | 1 | 1 |
| Sandra McCoy | Hot Chick | Tina | 1 | 1 |
| Steffani Brass | Sandy Dantini | Amy, Debbie | 1 | 2 |
| Tim Conway | Knuckles Pratt | Tim | 1 | 1 |
| Jennifer Aspen | Mrs. Ramsey, Stacy Cano | Stephanie | 2 | 1 |
| Andrea Bogart | Blonde Women | Gretchen | 1 | 1 |
| Cristine Rose | Grandma Giles | Lenore | 1 | 1 |
| Diane Farr | Marci Tobin | Rachel | 1 | 1 |
| Jennifer Jean Snyder | Sketch Artist | Terry | 1 | 1 |
| Jessica Collins | Missy | Gloria | 1 | 1 |
| Kelly Sry | Edward 40-Hands | Henry | 1 | 1 |
| Lilli Birdsell | Dr. Monica Warren | Louanne | 1 | 1 |
| Matt Roth | Sam Cooper | Greg | 1 | 1 |
| Nadia Bjorlin | Crystal Hasselbeck | Jill | 1 | 1 |
| Steve Lawrence | Mitch Urbana | Steve | 1 | 1 |
| Virginia Williams | Claudia Mason | Tricia | 1 | 1 |
| Cheryl White | Mrs. Faith Mason | Ruth | 2 | 1 |
| Clint Culp | Mike Ithaca, Security Guard | William | 2 | 1 |
| Amy Pietz | Rebecca McCormick | Angie | 1 | 1 |
| Charles Malik Whitfield | Ray | Police Officer | 1 | 1 |
| Chet Grissom | Restaurant Manager | Man | 1 | 1 |
| Elena Lyons | Julia Eastman | Susan | 1 | 1 |
| Jamal Duff | Security Guard | James | 1 | 1 |
| Jamie Rose | Sloane Jagov | Sloane Jagov | 1 | 1 |
| Joe Manganiello | Tom Parker | Alex | 1 | 1 |
| Kristin Bauer | Kenli Johnson | Laura | 1 | 1 |
| Lamont Thompson | SWAT Officer | Bruno | 1 | 1 |
| Nicole Steinwedell | Samantha Wilson | Veronica | 1 | 1 |
| Raymond Ma | Sammy | Mr. Park | 1 | 1 |
| Taylor Cole | Bianca | Melanie | 1 | 1 |
| Tina Morasco | Janice Cutler | Summer | 1 | 1 |
| Willie Garson | Bud Simmons / Sexy Kitty | Dr. Staven | 1 | 1 |
| Alessandra Torresani | Bree Lindale | Kathy | 1 | 1 |
| Danielle Bisutti | Theresa Shea | Vicki | 1 | 1 |
| Elizabeth Bogush | Eddie | Emily | 1 | 1 |
| Lexi Jourden | Suzy | Dakota | 1 | 1 |
| Meredith Giangrande | Susan Hodep | Nancy | 1 | 1 |
| Michael Lowry | Wes Tosterone | Wes Tosterone | 1 | 1 |
| Rib Hillis | Croix Richards | Justin | 1 | 1 |
| Will Sasso | Mason Lafoon | Andrew | 1 | 1 |
| Brett Wagner | Prison Cell Mate | Prison Cell Mate | 1 | 1 |
| Chris Coppola | Clyde | Douglas | 1 | 1 |
| Hollie Stenson | Destinee, Melinda Tucker | Destinee | 2 | 1 |
| John Burke | Detective Henry Ketchum | Detective Henry Ketchum | 1 | 1 |
| Ken Lerner | Jerry Nivens | Dr. Levine | 1 | 1 |
| Kristin Richardson | Eva | Tiffany | 1 | 1 |
| Shane Woodson | Overcoat Man | Man | 1 | 1 |
| Wayne Thomas Yorke | CSI Tech | Bob | 1 | 1 |
| Michael Edwin | Oddsmaker #1 | Proprietor | 1 | 1 |
| Ping Wu | Coroner | Coroner | 1 | 1 |
| Hope Allen | Jenna | Jenna | 1 | 1 |
| Ryan Heinke | N.D. Party-Goer | Slacker #2 | 1 | 1 |
| Dan Cole | Clown | Clown | 1 | 1 |
| Nakia Syvonne | Angel | Angel | 1 | 1 |
← CSI: Crime Scene Investigation × Two and a Half Men
Cast data from TVmaze, licensed CC BY-SA 4.0.