All 163 actors in both ER and Lie to Me*
163 actors have appeared in both ER and Lie to Me*, across 379 episodes. The most-credited is Michael Beach, Al Boulet in ER and James in Lie to Me*.
| Actor | In ER | In Lie to Me* | Eps | Eps |
|---|---|---|---|---|
| Michael Beach | Al Boulet | James | 19 | 1 |
| Monique Gabriela Curnen | Nurse Blanca | Detective Sharon Wallowski | 1 | 8 |
| Paula Malcomson | Meg Riley | Lightman's Mom | 8 | 1 |
| Gina Ravera | Dr. Bettina DeJesus | Paula | 13 | 1 |
| Garret Dillahunt | Steve Curtis | Eric Matheson | 5 | 1 |
| Hayley McFarland | Candice | Emily Lightman | 1 | 5 |
| Mekhi Phifer | Dr. Gregory Pratt | Ben Reynolds | 4 | 2 |
| Conor O'Farrell | Richard Abbott | Bernard Dillon | 2 | 3 |
| Michael B. Silver | Dr. Paul Myers | Personick's Attorney | 12 | 1 |
| Christopher Amitrano | Officer Hollis | Jim / Charlie One | 12 | 1 |
| Ashley Johnson | Dana Ellis | Valerie | 2 | 1 |
| Raphael Sbarge | Mr. Kirkendall | Prosser | 2 | 1 |
| Bruce Weitz | Alderman John Bright | Leo O'Sullivan | 3 | 1 |
| Dean Norris | Bomb Specialist Clark | Dawkins | 1 | 1 |
| Jackie Debatin | Judy | Cheyenne | 1 | 1 |
| Mark Rolston | Officer Thomas | Ed Komisky | 1 | 1 |
| Megan Follows | Christy Larkin | Lorraine Burch | 1 | 1 |
| Shoshannah Stern | Rosemary | Sarah | 1 | 3 |
| Maury Sterling | Dr. Nelson | Sully | 5 | 1 |
| Michael Dempsey | Mr. Beckwith | Herman Farr | 1 | 2 |
| Michael Raymond-James | Mr. Tunny, Stuart Moore | Gavin Howell | 2 | 1 |
| Shea Whigham | Bobby Kenyon | Jered Blunt | 2 | 1 |
| Mary Mara | Loretta Sweet | Krentz | 9 | 1 |
| Alicia Lagano | Tracy | Sheila Lake | 1 | 1 |
| Clea DuVall | Katie Reed | Michelle Russell | 2 | 1 |
| Katherine LaNasa | Janet Wilco | Laura Cross | 1 | 1 |
| Miguel Ferrer | Mr. Parker | FBI ASAC Bill Steele | 1 | 1 |
| Myra Turley | Monica Ford | Mrs. Perriman | 1 | 1 |
| Patrick Fischler | Chamber Tech | Olson | 1 | 1 |
| Michael Patrick McGill | Detective Ed Bernstein, Security #1, Officer Jeffries | Officer Barnes | 6 | 1 |
| Anthony Starke | Dr. Craig | Kyle Harmon | 2 | 1 |
| Alexa Nikolas | Megan Nesbitt | Amanda Dobar | 1 | 1 |
| Anna Gunn | Ikabo's Lawyer | Jenkins | 1 | 1 |
| Arye Gross | Kevin | Dr. Hamill | 1 | 1 |
| Carmen Argenziano | Howard Davis | Gus | 1 | 1 |
| Currie Graham | James | Eric Kuransky | 1 | 1 |
| Deidrie Henry | Nichelle Richardson | A'isha Walker | 1 | 1 |
| Glenn Morshower | Rick Decoyte | Col. Gorman | 1 | 1 |
| John Pyper-Ferguson | Tom Coggins | Jamie Cowley | 1 | 1 |
| Jose Pablo Cantillo | Juan Enriquez | Amadeo Valadez | 1 | 1 |
| Kari Coleman | Mona | Mary | 1 | 1 |
| Karina Logue | Radio Show Host | Gwen Burns | 1 | 1 |
| Keith Robinson | William White | Rudy | 3 | 1 |
| Kevin Tighe | Sgt. Pete Mattimore | Fletcher Bellwood | 1 | 1 |
| Lisa Waltz | Mrs. Wimbur | Mrs. Roland | 1 | 1 |
| Manny Montana | Football Orderly | Dax | 1 | 1 |
| Mark Harelik | James | DNI Mercier | 1 | 1 |
| Rance Howard | Dr. Oliver Kostin | Joe Metz | 1 | 1 |
| Richard Brooks | Mr. Freeman | City Inspector Mark Boulware | 1 | 1 |
| Robert Wisdom | Dr. Hammond | Bonds | 1 | 1 |
| Tzi Ma | Mr. Yeung | Mr. Chen | 1 | 1 |
| Hedy Burress | Joanie Moore | Steph Salinger | 4 | 1 |
| José Zúñiga | Eduardo Lopez | Detective Molina | 2 | 1 |
| Katie Mitchell | Shelley | Renee | 2 | 1 |
| Molly Price | Mrs. O'Fallon, Officer Faith Yokas | Deputy Director Messler | 2 | 1 |
| Barry Shabaka Henley | Detective | Dr. Olson | 1 | 1 |
| David Kaufman | Nick Dunn | Dan Felder | 2 | 1 |
| Emilio Rivera | Emilio Cardazco | Tony Calvo | 1 | 1 |
| Haley Ramm | Tasha | Amy | 1 | 1 |
| Jessica Tuck | Dr. Hemmings | Deputy Warden Lamb | 1 | 1 |
| Kristolyn Lloyd | Laura Banfield | Cara | 1 | 1 |
| Lee Tergesen | Mr. Mullen | Gordon Cook | 1 | 1 |
| Michelle Clunie | Gretchen | Jane Prescott | 1 | 1 |
| Rebecca Field | Psych Woman | Jenna Bynes | 1 | 1 |
| Rick Gonzalez | Jorge Escalona | Raul Campos | 1 | 1 |
| Shashawnee Hall | Detective Ford | Larry Bernardo | 2 | 1 |
| Tim Griffin | Captain John Evans | Principal Castle | 2 | 1 |
| Troy Winbush | Uniform Cop | Wallace | 1 | 1 |
| Randy Lowell | Dr. Shine | Mr. Knox | 3 | 1 |
| Bruce Nozick | Craig Simon | Mr. Dobson | 2 | 1 |
| Carole Gutierrez | Landlady | Mrs. Phillips | 1 | 1 |
| Charles Rahi Chun | Ben's Dad | Korean Man | 1 | 1 |
| Diane Baker | Louise Duffy | Judge Quinn | 1 | 1 |
| J.D. Cullum | Munchausen Patient | Dr. Dembeck | 1 | 1 |
| John Diehl | Johnson's Son | Charlie Everett | 1 | 1 |
| Jonathan Banks | Robert Truman | Ex FBI Agent Bitcher | 1 | 1 |
| Kathleen Gati | Stacy Coleman | Nurse | 1 | 1 |
| Lauren Bowles | Hannah | Valerie Blunt | 1 | 1 |
| Michael McGrady | Fire Captain Davis | Gil Wallace | 1 | 1 |
| Tomas Arana | State's Attorney Rifkin | Judge Simon | 1 | 1 |
| Andy Umberger | Dr. David Harvey | Peters | 2 | 1 |
| Jon Sklaroff | Bible Guy, Eddie Hainey | Larry | 2 | 1 |
| Michael Spellman | Dr. Jim Babinski | Married Guy | 3 | 1 |
| Andrew Rothenberg | Pauly Johnson | Kevin Rich | 1 | 1 |
| April Parker Jones | Joyce | Head Mistress Jonas | 1 | 1 |
| Carlos Lacamara | Ron Kennedy | Inspector Mike Adams | 1 | 1 |
| Chadwick Boseman | Derek Taylor | Cabe McNeil | 1 | 1 |
| Dan Martin | Lieutenant | Conrad Ricks | 1 | 1 |
| Frank Novak | Ted | Janitor | 1 | 1 |
| Fredric Lehne | Bum's Friend | Kevin Warren | 1 | 1 |
| J.R. Cacia | Ogilvie | Mr. Fitzgerald | 1 | 1 |
| Karis Campbell | Mrs. Kenig | Sarah Garcia | 1 | 1 |
| Mandy June Turpin | Viv Rafferty | Carolyn Hollin | 1 | 1 |
| Sara Mornell | Robin Gambrell | Janine | 1 | 1 |
| Scott Atkinson | Blake | Howard Taft | 1 | 1 |
| Bernard White | Addict seeking Rapid Detox | Imam Amir Hadad | 1 | 1 |
| Bradford Tatum | Detective Reitz | Peter Burch | 1 | 1 |
| Dean Chekvala | Mugger | Danny Pavelka | 1 | 1 |
| Howard Hesseman | Dr. James Broderick | Sam Hendricks | 1 | 1 |
| Isabella Hofmann | AIDS Clinic Doctor | Judge Kathleen Stark | 1 | 1 |
| Jack McGee | Rodney McMullen | Old Timer | 1 | 1 |
| James MacDonald | Officer Gary McWayne | Detective Riley | 1 | 1 |
| Jos Viramontes | Paul | Dr. Blake | 1 | 1 |
| Maestro Harrell | Todd | Tyrel | 1 | 1 |
| Maura M. Knowles | Mrs. Sawyer | Soccer Mom | 1 | 1 |
| Max Arciniega | Nick Vasquez | Miguel | 1 | 1 |
| Ned Schmidtke | Cal | Don Galpern | 1 | 1 |
| Randy Oglesby | PICU Doctor | Congressman Zeb Weil | 1 | 1 |
| Sean Blakemore | Mario | FBI Agent Irving | 1 | 1 |
| Shaun Duke | Detective, Painter | Mr. Grinwis | 2 | 1 |
| Alison La Placa | Female Lawyer | Diane Ktretschmer | 1 | 1 |
| B.K. Cannon | Tammy | Stacey | 1 | 1 |
| Cheryl White | Meryl Sites | Mayor Meredith Fallon | 1 | 1 |
| Dave Shalansky | Mr. Saltzman | Harvey | 1 | 1 |
| David Warshofsky | Hostage Negotiator | Owen Finnegan | 1 | 1 |
| Jenni Blong | Elaine Griswold | Mrs. Jackson | 1 | 1 |
| Kirk B.R. Woller | Prisoner Transport Officer | Mike Personick | 1 | 1 |
| Matthew Jones | Cop | Cop #1 | 1 | 1 |
| Michael Wiseman | Danny (Enforcer) | Prosecutor Crosby | 1 | 1 |
| Anjul Nigam | Ghandar | Shreyas Patel | 1 | 1 |
| Annamarie Kenoyer | Ruthie Pooler | Marly | 1 | 1 |
| Kurt Caceres | Luis Sanchez | Jack Garcia | 1 | 1 |
| Lenny Citrano | Martin | Public Defender | 1 | 1 |
| Molly Schaffer | Bar Patron | Stacy Felder | 1 | 1 |
| Nigel Gibbs | Matson | John Agro | 1 | 1 |
| Paul Keith | Paul | Mr. Welsh | 1 | 1 |
| Scott Klace | Chris Halpern | Martin Wexler | 1 | 1 |
| Scott Paulin | Dr. Kirsch | Gerald Cole | 1 | 1 |
| Ivo Nandi | Emilio | Churlish | 1 | 1 |
| Jake Thomas | Nick Riley | James Cole | 1 | 1 |
| Lou Richards | Perkins | Robert Bradin | 1 | 1 |
| Nadine Ellis | Mason's Wife | Female Secret Service Agent | 1 | 1 |
| Shannon McLemore | Lily | Camille | 1 | 1 |
| Steve Mize | Sachs | Nick | 1 | 1 |
| Steve Seagren | Zimmer | Museum Guard | 1 | 1 |
| Anthony Spagnola | Cop | Bob | 1 | 1 |
| Brian Catalano | Officer Cash | Viewing Room Guard | 1 | 1 |
| Gary Kraus | CJ | Bus Driver | 1 | 1 |
| Ronnie Gene Blevins | Nemo Baker | Hoodak | 1 | 1 |
| Teresa Huang | Vivian | Nurse | 1 | 1 |
| Gary Carlos Cervantes | Cop | ATF Asst. Dir. | 1 | 1 |
| Robert Alan Beuth | ICU Chief | Angry Guest | 1 | 1 |
| Alina Phelan | Mom | Joan | 1 | 1 |
| Christopher Darga | Wilson | Big Brother | 1 | 1 |
| Christopher Goodman | Andrew | Paramedic | 1 | 1 |
| Shelley Robertson | Tanya Phillips | Female Protester | 1 | 1 |
| Luis Moncada | Rogelio | Inmate #1 | 1 | 1 |
| Mark Ankeny | Electrician | Waylon | 1 | 1 |
| Michelle Anne Johnson | Sarah Irving | Medical Examiner | 1 | 1 |
| Michelle Noh | Kate | Corporate Woman | 1 | 1 |
| Craig Tsuyumine | Japanese Businessman 2 | Player #5 | 1 | 1 |
| Tom Choi | Zafares | Groom | 1 | 1 |
| Larry Herron | Mitch Kellems | Yager | 1 | 1 |
| Momo Yashima | Natsuki Barcenilla | Parole Board Member | 1 | 1 |
| Monique Edwards | Callie | Mrs. McNeil | 1 | 1 |
| Christopher T. Wood | Dr. Higgins | TSA Deputy | 1 | 1 |
| Lorenzo Callender | Officer Colby | Brian Denman | 1 | 1 |
| Terrence Hardy, Jr. | Lucas Kirk | Antwon Ricks | 1 | 1 |
| Ross Mackenzie | Fred | FEMA Tech | 1 | 1 |
| Emerson Brooks | Gonzalez | Sgt. Scott's Lawyer | 1 | 1 |
| Leesa Severyn | Physical Therapist | Reporter #2 | 1 | 1 |
| John Dugan | Young Cop | P.O.W. | 1 | 1 |
| Vincent Duvall | Father | Handsome Guy | 1 | 1 |
Cast data from TVmaze, licensed CC BY-SA 4.0.