All 105 actors in both ER and The Middle
105 actors have appeared in both ER and The Middle, across 546 episodes. The most-credited is John Cullum, David Greene in ER and Big Mike in The Middle.
| Actor | In ER | In The Middle | Eps | Eps |
|---|---|---|---|---|
| John Cullum | David Greene | Big Mike | 15 | 9 |
| Paul Hipp | Craig Turner | Reverend Tim Tom | 2 | 12 |
| Jeanette Miller | Beverly, Flora | Aunt Edie | 2 | 16 |
| Christopher Darga | Wilson | Mr. Farrar | 1 | 7 |
| Michael Patrick McGill | Detective Ed Bernstein, Security #1, Officer Jeffries | Cop #1 | 6 | 1 |
| Rick Overton | Mr. McNamara | Obadiah | 1 | 2 |
| Frances Bay | Georgia | Aunt Ginny | 1 | 10 |
| Courtney Gains | Ronnie | Phil Bickel | 1 | 1 |
| Keegan-Michael Key | Witkowski | Reverend Deveaux | 1 | 1 |
| Mary-Pat Green | Miss McDuffy | Mrs. Larimer | 1 | 3 |
| Michael Kostroff | Community Theater Director | Steve | 1 | 1 |
| Alexa PenaVega | Bonnie Howe | Morgan | 1 | 2 |
| Eddie Shin | Med Student Stanley Mao | Trivia Host | 2 | 1 |
| Lauri Johnson | Oncology Nurse | Mrs. Hilsabeck | 1 | 2 |
| Vernée Watson | April Wilson | Cashier | 2 | 1 |
| Edward Asner | Dr. James McNulty | Ben | 3 | 1 |
| Maurice G. Smith | Derek, Stanley Sherman | Cop #2, Neighbor Guy #1 | 2 | 2 |
| Thomas F. Duffy | Detective Henderson | Jack Meenahan | 1 | 3 |
| Diane Delano | Stella Willis, Delores | Police Officer | 5 | 1 |
| Audrey Wasilewski | Officer Wetterling | Jody | 1 | 1 |
| Charles Emmett | Derezin | Security Guy | 1 | 1 |
| Gina Hecht | Radiology Tech | Ms. Schaefer | 2 | 2 |
| Jonathan Palmer | Dr. Blevins | Rob | 1 | 1 |
| Joseph Whipp | Alan | Mike's Boss | 1 | 2 |
| Richard Gant | Mr. Lipson | Pastor Watkins | 1 | 1 |
| Sonya Eddy | Harriet, Student Affairs Secretary | Senora Porter | 3 | 2 |
| Carlease Burke | Policewoman | Ms. Teegarden, Professor Lynch | 1 | 2 |
| Charles C. Stevenson Jr. | Capt. Eddie | Old Hoosier | 1 | 2 |
| Liz Montgomery | Rosie | Lisa the Librarian | 1 | 2 |
| Richard Riehle | Mandrake Patient | Sheriff Dugan | 1 | 2 |
| Corbin Bleu | Little Boy | Luke | 1 | 1 |
| Dale Dickey | Mrs. Price | Sandy | 1 | 1 |
| Delaina Mitchell | Nicole | Janice Wagner | 1 | 1 |
| Gina Gallego | Instructor | Senora Pitts | 1 | 1 |
| Jeris Lee Poindexter | Nate, Rafe | Janitor, Old Man | 2 | 2 |
| Judith Hoag | Mrs. Brenner | Mrs. Jennings | 1 | 1 |
| Judy Kain | Thomas | Ms. Wright | 1 | 1 |
| Nancy Lenehan | Edie Harvell | Penny | 1 | 1 |
| Patricia Belcher | Ward Nurse | Mrs. Rettig | 1 | 1 |
| Rebecca Metz | Waitress | Saleslady | 1 | 1 |
| Valorie Hubbard | Mrs. Bulowski | Joe's Mom | 1 | 1 |
| Warren Davis | Kipness | Man #2 | 1 | 1 |
| Steven Lee Allen | Contractor | Bartender | 1 | 2 |
| Wesley Thompson | Fritz | Cop | 2 | 1 |
| Amy Farrington | Sandy Mader | Gail | 1 | 1 |
| Brian Chenoweth | Radiology Tech | BMV Examiner | 2 | 2 |
| Dagney Kerr | Hedda Lanford | Gloria | 1 | 1 |
| Ellen Geer | Mrs. Ferguson | Cynthia | 1 | 1 |
| Judith Drake | Greta | Old Lady | 1 | 1 |
| Mary Pat Gleason | Anne Parks | Mrs. Colavita | 1 | 1 |
| Michael Dempsey | Mr. Beckwith | Stan | 1 | 1 |
| Jon Curry | Karl | Corporate Guy #2, Jeffrey | 1 | 2 |
| Steffani Brass | Shelly Burke | Daughter, Girl #2 | 1 | 2 |
| Bill Chott | Glen Ashman | Wendell | 1 | 1 |
| Chane't Johnson | Betsy | Chess Mom | 1 | 1 |
| Christopher Goodman | Andrew | Man | 1 | 1 |
| Jerry Hauck | Umpire | Driver | 1 | 1 |
| Stacy Barnhisel | Nancy | Kristy | 1 | 1 |
| Toshi Toda | Japanese Businessman 1 | Takayuki's Dad | 1 | 1 |
| Tracy Weisert | Aunt Viola | Cashier | 1 | 1 |
| Brenda Ballard | Barb Weston | Food Court Patron #3 | 1 | 1 |
| Eve Brenner | Wilma | Mrs. Perkins | 1 | 1 |
| Gary Kraus | CJ | Coach | 1 | 1 |
| Linda Porter | Inga Paulson | Grandma Dot | 1 | 1 |
| Marilyn Sue Perry | Nurse Rogers | Woman #2 | 2 | 1 |
| Rick Hall | Detective in Larkin Case | Officer McCoy | 1 | 1 |
| Rusty Burns | Gerry | Sandy | 1 | 1 |
| Sally Ann Brooks | Allison | Jocelyn | 1 | 1 |
| William Charlton | Man | Guy #2 | 1 | 1 |
| B.K. Cannon | Tammy | Heather | 1 | 1 |
| Bill Stevenson | Clerk | Reggie | 1 | 1 |
| Cheyenne Wilbur | Garrity | Ed | 1 | 1 |
| Floyd Van Buskirk | Workman | Carny | 1 | 1 |
| J.J. Boone | Lenore Simkins | Nurse | 1 | 1 |
| Lise Simms | Emcee | Woman | 1 | 1 |
| Marianne Muellerleile | Mrs. Jarnowski | Liz | 1 | 1 |
| Marque Richardson II | Saga | Nick | 1 | 1 |
| Mike Randleman | Cop - 1 | flight attendant | 1 | 1 |
| Susan Grace | Gloria | Female Customer | 1 | 1 |
| Alex Alexander | Betty, Carol Weddington | Woman | 2 | 1 |
| Carole Gutierrez | Landlady | Confused Lady | 1 | 1 |
| Chris Coppola | Cop | Gene | 1 | 1 |
| Ping Wu | Mr. Cheung | Mr. Yamamoto | 1 | 1 |
| Aedin Mincks | Kid #1 | Boy | 1 | 1 |
| Betsy Baker | Dr. Wheeler | Patient | 1 | 1 |
| Christopher Gerse | Viktor | Pizza Guy | 1 | 1 |
| Duane R. Shepard, Sr. | Janitor | Judge | 1 | 1 |
| Dyllan Christopher | Hank | Andy | 1 | 1 |
| Lyle Kanouse | Mitch | Mr. Repsholdt | 1 | 1 |
| Rhonda Aldrich | Mrs. Reiser | Kathryn | 1 | 1 |
| Richard Pierre-Louis | Romeo | Coach | 1 | 1 |
| Ross Mackenzie | Fred | Waiter | 1 | 1 |
| Wayne Wilderson | Dr. Claypool | Principal Carson | 1 | 1 |
| Jon Paul Burkhart | Fred | Salesman | 1 | 1 |
| Lauri Hendler | Lenore Bee | Teacher | 1 | 1 |
| Phil Abrams | Rodney | Robert | 1 | 1 |
| Sarah Benoit | Melanie | Food Court Patron #4 | 1 | 1 |
| Andrew Astor | Tyler | Gerald | 1 | 1 |
| Bob Rumnock | Phillip Berk | Man | 1 | 1 |
| David Figlioli | Nolan | Security Man | 1 | 1 |
| E.J. Callahan | Drunk | Mr. Flurry | 1 | 1 |
| Gary Ballard | Arnold Plum | Janitor | 1 | 1 |
| Jerry Kernion | Bartender | Coach | 1 | 1 |
| Lynette DuPree | Athena | Woman #1 | 1 | 1 |
| Dwana White | Eliza | Student No. 2 | 1 | 1 |
Cast data from TVmaze, licensed CC BY-SA 4.0.