All 114 actors in both Grey's Anatomy and Marvel's Agents of S.H.I.E.L.D.
114 actors have appeared in both Grey's Anatomy and Marvel's Agents of S.H.I.E.L.D., across 603 episodes. The most-credited is Gaius Charles, Dr. Shane Ross in Grey's Anatomy and Ruben Mackenzie in Marvel's Agents of S.H.I.E.L.D..
| Actor | In Grey's Anatomy | In Marvel's Agents of S.H.I.E.L.D. | Eps | Eps |
|---|---|---|---|---|
| Gaius Charles | Dr. Shane Ross | Ruben Mackenzie | 22 | 1 |
| Briana Venskus-Vazquez | Adriana | Agent Piper | 1 | 20 |
| Jason O'Mara | Phillip Robinson | The Director Jeffrey Mace | 2 | 14 |
| Robert Baker | Dr. Charles Percy | Tobias Ford | 14 | 1 |
| Constance Zimmer | Dr. Alana Cahill | Rosalind Price | 5 | 8 |
| Peter MacNicol | Dr. Robert Stark | Professor Elliot Randolph | 7 | 2 |
| Dianne Doan | Molly Tran | Kora | 8 | 6 |
| J. August Richards | Young Dr. Richard Webber | Mike Peterson / Deathlok | 2 | 12 |
| Catherine Dent | Cathy Rogerson | General Hale | 1 | 10 |
| Coy Stewart | Chase's Friend | Flint | 1 | 9 |
| Sherri Saum | Allison Robin Brown | Atarah | 2 | 3 |
| Nora Zehetner | Dr. Reed Adamson | Viola | 10 | 2 |
| Patrick Cavanaugh | Vince Cruse | Agent Burrows | 1 | 12 |
| Cullen Douglas | Dr. Bob Richardson, Mr. Arnold | Edison Po | 2 | 3 |
| Maya Stojan | Tatiana Flauto | Kara Palamas | 1 | 8 |
| Barry Shabaka Henley | Mr. Patterson | Dr. Marcus Benson | 1 | 5 |
| José Zúñiga | Anthony Meloy | Eli Morrow | 1 | 5 |
| Lilli Birdsell | Emily Rochester | Lucy Bauer | 1 | 5 |
| Derek Phillips | Dale Winick | Agent O'Brien | 2 | 3 |
| Shannon Lucio | Amanda | Debbie | 3 | 2 |
| Mackenzie Astin | Danny Wilson | Tim Maguire | 2 | 1 |
| Alexander Wraith | Oscar Hallis | Agent Anderson | 1 | 6 |
| Arlene Santana | Nurse | Reporter #2 | 10 | 1 |
| Bethany Joy Lenz | Jenny | Stephanie Malick | 2 | 2 |
| Phil Abrams | Dr. Jim Nelson | Harold Simcoe | 3 | 1 |
| Zibby Allen | Nurse Zibby | Lt. Evans | 6 | 2 |
| Shainu Bala | Dennis | Trevor Khan | 1 | 4 |
| Tsai Chin | Helen Rubenstein | Lian May | 4 | 1 |
| Dylan Bruno | Griffith Lewis | Rooster | 2 | 1 |
| Dylan Minnette | Ryan | Donnie Gill | 1 | 2 |
| Josh Clark | Lenny Shulte | Roger | 1 | 1 |
| Raquel Gardner | Claire | Carla Talbot | 1 | 6 |
| Glenn Morshower | Walter | General Jacobs | 1 | 2 |
| Patrick Fabian | Dr. Oliver Lebackes | Senator Gaius Ponarian | 2 | 1 |
| Robert Belushi | TV Announcer | Jimmy MacKenzie | 1 | 2 |
| Adam Kulbersh | Tommy | Kenneth Turgeon | 1 | 3 |
| Assaf Cohen | Aamir Elshami | Translator | 1 | 1 |
| Erin Way | Donna Woods | Petra Larsen | 1 | 1 |
| Brandon Molale | Beefy Patient | Smith | 1 | 2 |
| Chen Tang | Dave | Agent Kim | 1 | 2 |
| Michael McGrady | Stanley Singer | Samuel Voss | 1 | 2 |
| Rya Kihlstedt | Claire | Lady Basha | 1 | 2 |
| Sarayu Blue | Pam | Dr. Jazuat | 1 | 2 |
| Taj Speights | Jonah Mays | Burnell | 1 | 2 |
| Stephen Bishop | Firefighter | Agent Brandon Gamble | 2 | 2 |
| Amy Acker | Dr. Kathleen Shepherd | Audrey Nathan | 1 | 1 |
| Austin Basis | Devin | Russell Feldman | 1 | 1 |
| Dale Waddington Horowitz | OB Resident | Dr. Lingenfelter | 2 | 1 |
| Jeffrey Muller | Code Team Person | Agent Kaminsky | 1 | 3 |
| Louis Ozawa Changchien | Steve Lee | Chan Ho Yin | 2 | 1 |
| Skyler James | Pete Hover | Chris Adler | 1 | 2 |
| Stewart Skelton | Dr. Fischer | Chief Wellins | 1 | 2 |
| Tzi Ma | Mr. Patterson | Agent Quan Chen | 1 | 1 |
| Liberté Chan | Reporter | News Reporter | 2 | 2 |
| Brian Tee | Andrew 'Andy' Billings | Toshiro Mori | 2 | 1 |
| Mark Atteberry | Brian Williams | Kurt Vogel | 1 | 2 |
| Nicole J. Butler | Jess | Aunt Mindy | 1 | 2 |
| Andrew Thacher | Sean | Rowan Lawyer #1 | 1 | 1 |
| Artemis Pebdani | Sharon Peters | L.T. Koenig | 1 | 1 |
| Hugh Holub | Dr. Ben Warren | Tightly-Wound Scientist | 1 | 1 |
| Jean Louisa Kelly | Rose Ward | Dr. Keen | 1 | 1 |
| Jeris Lee Poindexter | Mr. Strickland | Older Man | 1 | 1 |
| Larry Clarke | Paul | Tom | 1 | 1 |
| Micah Nelson | Robbie Reeves | Boy | 1 | 1 |
| Mike Miller | Intern | S.H..I.E.L.D. Medic | 1 | 1 |
| T.J. Ramini | Mr. Al-Hasan | Carlo Mancini | 1 | 1 |
| Gabriel Sousa | Edgar | Durant | 1 | 2 |
| Mark Berry | AA Member | Admiral Jolnes | 1 | 2 |
| Wilmer Calderon | Raul Aranda | Idaho | 1 | 2 |
| Antonio Leon | Detective Mitch Proust | Bahranian Soldier | 1 | 1 |
| Eva La Dare | Police Officer #2 | Jan | 1 | 1 |
| Markus Flanagan | Ed Hamilton | Rowan Hamilton | 1 | 1 |
| Mickey Maxwell | Minister | Officer | 1 | 1 |
| Rick Gifford | Davis Calder | Adam Cross | 1 | 1 |
| Shelley Robertson | Arlene Travis | Michelle Caldwell | 1 | 1 |
| Tyler Ritter | Paul Zarr | Thomas Ward | 1 | 1 |
| Ashley Platz | Claire Conway | Young Mystery Woman | 1 | 1 |
| Damian Gomez | Man | Coffee Vendor | 1 | 1 |
| Dorian Gregory | Kenneth Turner | Undersecretary Walter Thomas | 1 | 1 |
| Kimberley Drummond | Allie Best | Agent Crawford | 1 | 1 |
| Ronnie Alvarez | Barista | Uniformed Officer | 1 | 1 |
| Shakira Barrera | Young Mom | Agent King | 1 | 1 |
| Amy Tolsky | Tonya Orvis | Woman | 1 | 1 |
| Brandon Ford Green | Dr. Allen | Third Soldier | 1 | 1 |
| Cantrell Harris | Rescue Worker | Agent Fisher | 1 | 1 |
| Josh Daugherty | Ken Daniels | Kyle Zeller | 1 | 1 |
| Ludwig Manukian | Bus Driver | Conductor | 1 | 1 |
| Alan Heitz | Applicant #1 | Bookish Man | 1 | 1 |
| Alastair Bayardo | Social Worker | Agent McCafferty | 1 | 1 |
| Graham Sibley | Noah | Professor Steger | 1 | 1 |
| Jaime Alvarez | Suited Man | Lead Officer | 1 | 1 |
| Kevin Sifuentes | Manoj Joshi | Technician | 1 | 1 |
| Mark Fite | Jared Cassidy | Dr. Joseph Getty | 1 | 1 |
| Rich Ceraulo Ko | Brian | Soldier #1 | 1 | 1 |
| Tom Simmons | Bob | Cop | 1 | 1 |
| Antonio Aaron | Police Officer #2 | Officer Kennedy | 1 | 1 |
| Brett Edwards | Lieutenant Matthews | Army Private | 1 | 1 |
| Doug Simpson | Phil Leggett | Emissary | 1 | 1 |
| Matt Ferrucci | Closing Surgeon | S.H.I.E.L.D. Agent | 1 | 1 |
| Byron McIntyre | Colonel | Bartender | 1 | 1 |
| Jarrod Crawford | Dr. Oslow | Lead Hydra Agent | 1 | 1 |
| Josh Fingerhut | Police Officer | Bartender | 1 | 1 |
| Karole Foreman | Olivia | Waitress | 1 | 1 |
| Maz Siam | Emir's Chief of Staff | The Sheikh | 1 | 1 |
| Rocky McMurray | Hunter | General Fischer | 1 | 1 |
| Chase Kim | Lawyer | Waiter | 1 | 1 |
| Nick Roth | Tim Bowman | Second Hydra Agent | 1 | 1 |
| Nico David | Gabe | Boy | 1 | 1 |
| Darren Dupree Washington | Reporter | Interrogating Agent | 1 | 1 |
| Natalie Smyka | Student | Patient #5 | 1 | 1 |
| Mark Daneri | Tenant #4 | Wisconsin Congressman | 1 | 1 |
| J.B. Tadena | Nurse Adam | Private Tilden | 1 | 1 |
| John Churchill | Charlie | Father | 1 | 1 |
| Stephanie Maura Sanchez | Admitting Nurse | Leticia | 1 | 1 |
← Grey's Anatomy × Marvel's Agents of S.H.I.E.L.D.
Cast data from TVmaze, licensed CC BY-SA 4.0.