All 128 actors in both Grey's Anatomy and This Is Us
128 actors have appeared in both Grey's Anatomy and This Is Us, across 573 episodes. The most-credited is Kate Burton, Dr. Ellis Grey in Grey's Anatomy and Barbara in This Is Us.
| Actor | In Grey's Anatomy | In This Is Us | Eps | Eps |
|---|---|---|---|---|
| Kate Burton | Dr. Ellis Grey | Barbara | 29 | 2 |
| Amanda Leighton | Sarah Cassidy | Teenage Sophie | 1 | 19 |
| Brandon Scott | Intern Ryan | Corey Lawrence | 13 | 3 |
| Vanessa Bell Calloway | Lucinda Gamble | Edie | 2 | 7 |
| Debra Mooney | Evelyn Hunt | Mrs. Peabody | 13 | 1 |
| Sophia Bush | Dr. Cass Beckman | Lizzie | 7 | 1 |
| Laura Niemi | Cynthia | Marilyn Pearson | 1 | 6 |
| Brittany Ishibashi | Talia | Tracy | 1 | 2 |
| Sumalee Montano | Lena McCallister | Dr. Gail Jasper | 1 | 2 |
| Wynn Everett | Christy Cornell | Shelly | 1 | 5 |
| Annie Funke | Kendra | Ellie | 1 | 4 |
| Phylicia Rashad | Nell Timms | Carol Clarke | 1 | 4 |
| Janora McDuffie | Janet Anderson | Librarian Mom | 6 | 1 |
| Arianna Ortiz | Jessica Schoman | Dr. Sara Arroyo | 1 | 3 |
| Debra Jo Rupp | Jo's Therapist | Linda | 1 | 4 |
| Marla Gibbs | Joyce Ward | Diner Customer | 4 | 1 |
| Michael O'Neill | Gary Clark | Arlo | 4 | 1 |
| Carl Lumbly | Kurt Walling | Abe Clarke | 1 | 2 |
| Jennifer Westfeldt | Jen Harmon | Claire | 3 | 1 |
| Meryl Hathaway | Tovah Freedman | Linda | 3 | 1 |
| Phil Abrams | Dr. Jim Nelson | Dr. Weiss | 3 | 1 |
| Reggie Watkins | Ashley Wright's Husband | Shooter | 1 | 3 |
| Dawnn Lewis | Jamarah Blake | Rosemary / Apartment 3 Resident | 3 | 2 |
| John Pollono | Charlie Bilson | Tyler | 1 | 5 |
| Anthony Hill | Dr. Winston Ndugu | Marshall Winston | 1 | 1 |
| Assaf Cohen | Aamir Elshami | Dr. David Monroe | 1 | 1 |
| Briana Venskus-Vazquez | Adriana | Vanessa | 1 | 2 |
| Gary Kraus | Louis Cardon | Gus | 1 | 1 |
| Karly Rothenberg | Ruth Bennet | Nurse | 1 | 1 |
| Logan Shroyer | Pete Gabriel | Young Kevin (15) | 1 | 4 |
| Rebecca Metz | Brenda Lawson | Martina | 1 | 1 |
| Rebeka Montoya | Marisela | Julie | 1 | 2 |
| Uyoata Udi | Curtis James | Ervin | 2 | 1 |
| William Allen Young | Morris Haynes | Councilman Wilkins | 1 | 2 |
| Joyce Guy | Ms. Henry | Dr. Jane Welsh | 3 | 1 |
| Kila Packett | Paramedic #2 / Paramedic, EMT | Boomer | 3 | 1 |
| Charlie Robinson | Leo Paulson | Don Robinson | 1 | 2 |
| James Moses Black | Duncan | Reverend Hawley | 1 | 2 |
| John Billingsley | Jacob Nolston | Bill Weston | 2 | 1 |
| Scott Michael Campbell | Mr. Hubble | Commanding Officer Sheehan | 1 | 2 |
| Susan Santiago | Blanca Rodriguez | Dr. Angela Whitaker | 1 | 2 |
| Adam Bartley | Dave Morton | Duke | 1 | 3 |
| Brett Tucker | Lucas Ripley | Band Manager | 1 | 1 |
| Jamie Chung | Trina Paiz | Ava | 1 | 1 |
| John Rubinstein | Keith Kalber | Ron Schiller | 1 | 3 |
| Rosalind Chao | Kathleen Patterson | Anna | 1 | 1 |
| Sonia Jackson | Patient #1 | Female Doctor | 1 | 1 |
| Stefanie Black | Roxie Meyers | Charlotte Everly | 1 | 1 |
| Katie Lowes | Blood Donor | Arielle | 1 | 2 |
| LisaGay Hamilton | Dr. Connie Ryan | Aunt Mae | 2 | 1 |
| Sara Paxton | Leticia Gregory | Kathryn | 2 | 1 |
| Adargiza De Los Santos | Nadine Talbott | Cousin Tori | 1 | 1 |
| Brandee Steger | Mrs. Lima | Improv Actor | 1 | 1 |
| Brian Oblak | Daniel Rudin | Joe | 1 | 2 |
| David DeLuise | Charlie Connor | Bill Lundy | 1 | 1 |
| Joshua Malina | Seth Hammer | Car Crash Victim | 1 | 1 |
| Lena Waithe | Dr. Evynn Moore | Animal Shelter Clerk | 2 | 1 |
| Melissa Center | Ashley Glazier | Landlady | 3 | 1 |
| Michael James Lazar | Phillip | Joseph | 1 | 1 |
| Molly Hagan | Jackie | Grace Pendergrass | 1 | 1 |
| Nancy Linari | Sophie's Daughter | Mrs. Sandburg | 1 | 1 |
| Skye P. Marshall | Mary Hodges | Trish Lawrence | 1 | 1 |
| Wayne Lopez | Paramedic #2 | Ned | 4 | 1 |
| Michael Hagiwara | Charles Hyatt | Dr. Takebe | 1 | 2 |
| Ava DeVoe | Matty | Samantha | 3 | 1 |
| Carlease Burke | Mrs. Gates | Bernice | 1 | 1 |
| Jeremiah Birkett | John McMurdo | Brett | 1 | 1 |
| Kate Blumberg | Daisy | Kate's Flight Seat Mate | 1 | 1 |
| La Monde Byrd | Martin Sterling | Congressman Andrew Reeves | 1 | 1 |
| Ren Hanami | Mrs. Chen | Dr. Salzman | 1 | 1 |
| Shelley Robertson | Arlene Travis | Déjà's Father | 1 | 1 |
| Wendy Schenker | Nervous Tenant | Grocery Store Woman | 1 | 1 |
| Des Epps | Wounded Corporal | Adult Malick | 1 | 2 |
| Akira Akbar | Amethyst | Young Beth | 1 | 1 |
| Caryn West | Maura Brooks | Dr. Lee | 2 | 1 |
| Clayton Farris | Kevin | P.R. Person | 1 | 1 |
| Grace Shen | Woman | Waitress | 1 | 1 |
| Mark Atteberry | Brian Williams | Brad | 1 | 1 |
| Paul Zies | Biker Dude | Bartender | 1 | 1 |
| Ronobir Lahiri | Mr. Hanson | Garuda Singh | 1 | 1 |
| Sam Anderson | Michael Whitman | Judge Walter Crowder | 1 | 1 |
| Stewart Skelton | Dr. Fischer | Father Williams | 1 | 1 |
| Tacey Adams | Widow Amos | Judge | 1 | 1 |
| Thomas Anthony Jones | Surgeon 1 | Kurt | 1 | 1 |
| Vince Cefalu | ND Patient | Grocery Store Manager | 1 | 1 |
| Misha Gonz-Cirkl | Social Worker | Dr. Miranda Ruiz | 2 | 1 |
| Angela E. Gibbs | Mrs. Rollins | Older Laurel | 1 | 1 |
| Ayesha Harris | Charlie Yarrington | Lawyer | 1 | 1 |
| Betsy Baker | Barb | Waitress | 1 | 1 |
| Erik Audé | Paramedic Jonathan | Thug #1 | 1 | 1 |
| Jack Landron | Chaplain | Man on the Stage | 1 | 1 |
| John Deignan | Vincent Freeman | Bartender | 1 | 1 |
| Lak Rana | N.D. Peds Surgeon | Brian | 1 | 1 |
| Char Sidney | Flight Doc, Paramedic #1 | Nurse #1 | 2 | 1 |
| Cinda Adams | Wendy Hayes | Paula | 1 | 1 |
| Daniel Tatar | Hotel Clerk #1 | Realtor | 1 | 1 |
| Eamon Hunt | Judge Brentner | Doctor | 1 | 1 |
| Jane Daly | Meredith's Examiner | Sally | 1 | 1 |
| Jill Remez | April's Examiner | Ms. Gathier | 1 | 1 |
| Kelvin Brown | Frankie | Ronny | 1 | 1 |
| Merrick McCartha | Karl | Lester | 1 | 1 |
| Wendy Braun | Captain LeVantine | Linda Darroe | 1 | 1 |
| Melissa Oliver | Perfusionist | Anesthesiologist | 2 | 1 |
| Aly Mawji | Dr. Russell | Amir | 1 | 1 |
| Angela Landis | Flight Attendant | Nurse Laurie | 1 | 1 |
| Jaylee Chen | Woman | Jessica | 1 | 1 |
| Michael Andrew Baker | Frank Nelstadt | Doctor | 1 | 1 |
| Rob Mainord | Procurement Surgeon | Pastor | 1 | 1 |
| Taneka Johnson | Nurse Khadijah | Taneka, Woman from the Crowd | 1 | 2 |
| David Grant Wright | Mr. Burton | Pritchard | 1 | 1 |
| Lisa Schurga | Karissa Skolaski | Stage Manager | 1 | 1 |
| Sally Ann Brooks | Marie Lamott | Nurse Iris | 1 | 1 |
| Stacy Barnhisel | Gretchen | Amy | 1 | 1 |
| Carrie Gibson | Security Guard | Stable Hand | 1 | 1 |
| Kelly Jenrette | Deb | Megan Brooks | 1 | 1 |
| Alfred Woodley | Driver | Man | 2 | 1 |
| Amie Farrell | Marnie | Jogger Julia | 1 | 1 |
| Veena Bidasha | Tina | Dr. Molani | 1 | 1 |
| Dar Dixon | Dr. Krogan | Buchanan | 1 | 1 |
| Jeffrey Muller | Code Team Person | Doctor | 1 | 1 |
| Alan Heitz | Applicant #1 | Rick | 1 | 1 |
| Michael Albala | Harvest Surgeon | Dr. Schneider | 1 | 1 |
| Anthony M. Bertram | Pastor | Chuck | 1 | 1 |
| Brian Chenoweth | Scared Guy | Lab Supervisor | 1 | 1 |
| Christopher Guyton | Big Foot | Male Voter | 1 | 1 |
| John Gloria | Rob Kane | Carl | 1 | 1 |
| Nina Gosiengfiao | Picture Perfect Interviewee | Hostess | 1 | 1 |
| Brandon Ford Green | Dr. Allen | Waiter | 1 | 1 |
Cast data from TVmaze, licensed CC BY-SA 4.0.