All 100 actors in both Grey's Anatomy and Two and a Half Men
100 actors have appeared in both Grey's Anatomy and Two and a Half Men, across 729 episodes. The most-credited is Chris O'Donnell, Finn Dandridge in Grey's Anatomy and Bill in Two and a Half Men.
| Actor | In Grey's Anatomy | In Two and a Half Men | Eps | Eps |
|---|---|---|---|---|
| Chris O'Donnell | Finn Dandridge | Bill | 10 | 1 |
| Rebecca McFarland | Tara Parker | Leanne | 2 | 8 |
| John O'Brien | Lab Tech Jeffrey | Waiter | 13 | 1 |
| Deanna Russo | Nola Marques | Laurel | 2 | 3 |
| Joel Murray | ICE Agent Martin Fields | Petey, Doug, Nick | 1 | 4 |
| Katherine LaNasa | Kalpana Vera | Lydia | 1 | 4 |
| Missi Pyle | Dr. Nicole Baylow | Delores Pasternak | 1 | 4 |
| Coby Ryan McLaughlin | Chad Anderson | Jeremy | 1 | 2 |
| Kimberly Quinn | Reena Thompson | Donna | 1 | 2 |
| Annie Potts | Joyce Bosco | Lenore | 1 | 1 |
| Darryl Sivad | Justice of the Peace | Cab Driver | 1 | 1 |
| David Denman | Rick Jacobs | Jack | 1 | 1 |
| Dylan Minnette | Ryan | Little Charlie | 1 | 1 |
| Jen Lilley | Kara Fisher | Bridesmaid #4 | 1 | 1 |
| Kimberly Hébert Gregory | Deborah Curzon | Lisa | 1 | 1 |
| Lee Garlington | Farah Linden | Peggy | 1 | 1 |
| Marion Ross | Betty Donahue | Margaret | 1 | 1 |
| Myndy Crist | Diane Hanson | Wendy | 1 | 1 |
| Paulina Olszynski | Lisa | Trudy | 1 | 1 |
| Stephanie Erb | Mrs. Gantry | Mrs. Schmidt | 1 | 1 |
| Meagen Fay | Paula | Martha | 1 | 2 |
| Michael Patrick McGill | Bob Corson | Joseph, Officer Smith | 1 | 2 |
| Wayne Wilderson | Bill Adams | Dad, Roger | 1 | 2 |
| Amy Hill | Joanne | Mrs. Wiggins | 1 | 1 |
| Bellamy Young | Kathy | Diane | 2 | 1 |
| Bill Smitrovich | Dr. Walter Carr | Rick | 2 | 1 |
| Brian George | Emile Flores | TV Narrator | 1 | 1 |
| Daya Vaidya | Paola Bright | Lucy | 1 | 1 |
| Diane Farr | Lila Davis | Rachel | 1 | 1 |
| Erinn Hayes | Cathy Becker | Gretchen | 1 | 1 |
| Ernie Grunwald | Gary Rubin | Clinician | 1 | 1 |
| Eugene Byrd | Danny Ford | Lenny | 1 | 1 |
| Eve Gordon | Mary Chapman | Brenda | 1 | 1 |
| Frances Fisher | Betty Johnson | Priscilla Honeycutt | 1 | 1 |
| George Coe | Ed Bullard | Victor | 1 | 1 |
| Jeff Staron | Tom Vinson | Barista | 1 | 2 |
| Kate Miner | Mindy Wallace | Nadine | 1 | 1 |
| Kay Panabaker | Emma Anderson | Sophie | 1 | 1 |
| Larry Cedar | Dr. Cohn | Announcer, Policeman #1 | 1 | 2 |
| Marilu Henner | Mrs. Moser | Linda | 1 | 1 |
| Mark Chaet | Judge | Doctor | 1 | 1 |
| Meeghan Holaway | Representative for the Doctors | Brenda | 3 | 1 |
| Nicholas Gonzalez | Clark West | Baker | 1 | 1 |
| Dale Waddington Horowitz | OB Resident | Woman | 2 | 1 |
| Jim Lau | Examiner #4 | Chinese Man | 2 | 1 |
| Aaron Refvem | Jackson Prescott | Chuck | 3 | 1 |
| Abigail Mavity | Ariel Williams | Brianna | 1 | 1 |
| Amy Farrington | Mary May | Kathleen | 1 | 1 |
| Andre Ware | Dr. Evett | Officer Chamberlan | 1 | 1 |
| Angela Lin | Barbara Yu | Laura | 1 | 1 |
| Audrey Wasilewski | Nicole Waldman | Megan | 1 | 1 |
| Bre Blair | Lauren Pailey | Rachel | 1 | 1 |
| David Grant Wright | Mr. Burton | John | 1 | 1 |
| Elise Robertson | Ms. Johnson | Second Nurse | 1 | 1 |
| Elizabeth Ho | Molly | Jasmine | 1 | 1 |
| Ewan Chung | Tech Guy | Attendant | 1 | 1 |
| Gwendoline Yeo | Michelle Carpio | Computer Voice | 1 | 1 |
| Jamal Thomas | Larry the Paramedic | Fireman #2 | 1 | 1 |
| Jennifer Jean Snyder | Reporter | Terry | 1 | 1 |
| Jessica Collins | Denise | Gloria | 1 | 1 |
| June Squibb | Dr. Elsie Clatch | Margaret | 1 | 1 |
| Kelly Sry | Tech | Henry | 1 | 1 |
| Lilli Birdsell | Emily Rochester | Louanne | 1 | 1 |
| Matt Roth | Michael Beglighter | Greg | 1 | 1 |
| Nadine Ellis | Melissa Walker | Jeanie | 1 | 1 |
| Nicole J. Butler | Jess | Mother | 1 | 1 |
| Kelly King | Sara, Soccer Mom | Kelly | 2 | 1 |
| Will Sasso | Jet / Maintenance Worker | Andrew | 2 | 1 |
| Amy Pietz | Shelby Lewis | Angie | 1 | 1 |
| Brit Morgan | Erica Marsh | Jill | 1 | 1 |
| Chet Grissom | Uncle Pat | Man | 1 | 1 |
| Jamie Rose | Lena | Sloane Jagov | 1 | 1 |
| Jennifer Aspen | Elaina | Stephanie | 1 | 1 |
| Jesse Mackey | Guard #4 | Larry | 1 | 1 |
| Justin Alston | CT Tech | Employee | 1 | 1 |
| Karen Y. McClain | Reaves | Chrissy | 1 | 1 |
| Michael Medico | Martin | Bartender | 1 | 1 |
| Michael Merton | Dexter | Photographer | 1 | 1 |
| Nancy Linari | Sophie's Daughter | Woman's Voice | 1 | 1 |
| Rico E. Anderson | Donnie | M.P. Searle | 1 | 1 |
| Sarayu Blue | Pam | Emily | 1 | 1 |
| Treisa Gary | Beth | Nurse Shelby | 1 | 1 |
| Alicia Hannah | Jasmine | Lotus | 1 | 1 |
| Angelique Cabral | Rhys's Mother | Shannon | 1 | 1 |
| Barry Livingston | Wayne Sheehan | Sam | 1 | 1 |
| Bob Rumnock | ND Doctor | Minister | 1 | 1 |
| Cheryl White | Lynn Connors | Ruth | 1 | 1 |
| Clint Culp | Mr. Quaid | William | 1 | 1 |
| Daniel Steven Gonzalez | Paramedic Garza | Paramedic | 1 | 1 |
| Danielle Bisutti | Liz Langer | Vicki | 1 | 1 |
| Debra Holt | Big Man's Wife | Overweight Woman | 1 | 1 |
| Elizabeth Bogush | Gia | Emily | 1 | 1 |
| Hugh Holub | Dr. Ben Warren | man | 1 | 1 |
| Tristan Byon | Max Spencer | Boy | 1 | 1 |
| Christina Scherer | Lauren | Jenny | 1 | 1 |
| Jim Grollman | Bus Driver | Cashier | 1 | 1 |
| Ronobir Lahiri | Mr. Hanson | Dr. Gollygupta | 1 | 1 |
| Sonia Jackson | Patient #1 | Andrea | 1 | 1 |
| Abbie Cobb | Francis "Frankie" Keller | Gabby | 1 | 1 |
| Ping Wu | Seymour Glass | Coroner | 1 | 1 |
← Grey's Anatomy × Two and a Half Men
Cast data from TVmaze, licensed CC BY-SA 4.0.