All 105 actors in both NYPD Blue and The X-Files
105 actors have appeared in both NYPD Blue and The X-Files, across 479 episodes. The most-credited is James Pickens, Jr., Nathan Foster in NYPD Blue and Deputy Director Alvin Kersh in The X-Files.
| Actor | In NYPD Blue | In The X-Files | Eps | Eps |
|---|---|---|---|---|
| James Pickens, Jr. | Nathan Foster | Deputy Director Alvin Kersh | 1 | 22 |
| Justine Miceli | Det. Adrianne Lesniak | Ariel Luria | 13 | 1 |
| Steven Williams | Lt. Nathan Stackhouse | Mr. X | 1 | 13 |
| James Handy | Borough Commander Haverill | Detective Alan Cross | 7 | 1 |
| Charles Cioffi | Raymond Schelzo | Section Chief Scott Blevins | 1 | 5 |
| Michael B. Silver | A.D.A. Leo Cohen | Howard Grodin | 4 | 2 |
| Peter Boyle | Dan Breen | Clyde Bruckman | 5 | 1 |
| Bradley Whitford | Norman Gardner | Dr. Daniel Trepkos | 4 | 1 |
| Mark Pellegrino | Steve Dansick, Fran Watkins, Stanley Struel | Derwood Spinks | 4 | 1 |
| Titus Welliver | Dr. Mondzac | Doug Spinney | 4 | 1 |
| Conor O'Farrell | Det. Stuart Morrisey | Sheriff Ciolino | 3 | 1 |
| Scott Allan Campbell | IAB Sgt. Jerry Martens | Jeff Smoodge | 6 | 2 |
| Daniel Benzali | James Sinclair, Esq. | Colonel Jacob Wharton | 5 | 1 |
| Don Swayze | Alex | Terry Pruit | 2 | 1 |
| Giovanni Ribisi | Bruce Mackie | Darin Peter Oswald | 2 | 1 |
| Jack McGee | Bob Daniels, Fort Lee Sergeant | Bob Damphouse | 2 | 1 |
| John Finn | Jimmy "Socks" Matloe | Michael Kritschgau | 1 | 5 |
| Nick Chinlund | Weldon Small | Donald Eddie Pfaster | 1 | 2 |
| Susanna Thompson | Joyce Novak | Michelle Generoo | 2 | 1 |
| Willie Garson | Henry Coffield | Henry Weems, Quinton 'Roach' Freely | 1 | 2 |
| Aaron Paul | Marcus Denton | Winky | 1 | 1 |
| Cec Verrell | Gail Keller | Lula Phillips | 1 | 1 |
| Erick Avari | Rajesh | Dr. Herb Fountain | 1 | 1 |
| Michael Bowen | David Tierney | Dwight Cooper | 1 | 1 |
| Robert LaSardo | Luis Hernandez | Cissy Alvarez | 1 | 1 |
| Jay Acovone | Raymond DiSalvo | Duffy Haskell, Det. Joe Curtis | 2 | 3 |
| Chris Ellis | Marshal | Sheriff Lance Hindt | 2 | 1 |
| Fredric Lehne | Mark Drennan | Arthur Dales | 1 | 2 |
| Mark Rolston | Leon Broadus | Bud LaPierre, Richard Odin | 1 | 2 |
| Ramy Zada | Harold Rutansky | Joe Cutrona | 2 | 1 |
| Tobin Bell | Donald Selness, Jerry the Artist | Daryl Weaver | 2 | 1 |
| Wendie Malick | Susan Wagner | Assistant Director Maslin | 2 | 1 |
| Kirk B.R. Woller | Mitch | Agent Gene Crane | 1 | 5 |
| Clayton Rohner | Earl Padzik | Daryl Mootz | 1 | 1 |
| Dean Norris | Father Jerry Downey | U.S. Marshal Tapia | 3 | 1 |
| Debra Christofferson | Geri Turner | Pat Verlander | 1 | 1 |
| George Gerdes | Louis Foreman | Reverend Calvin Hartley | 1 | 1 |
| Glenn Morshower | Special Agent Wilson | Aaron Starkey | 1 | 1 |
| James Sloyan | Barry Ulin | Dr. Frank Nollette | 1 | 1 |
| Jason Beghe | Julian Kerbis | Ranger Larry Moore | 1 | 1 |
| Leland Orser | Les Treet, Zeppo Marchansky | Jason Ludwig | 2 | 1 |
| Leon Russom | William Crawford | Detective Miles | 1 | 2 |
| Michael MacRae | Det. Ronnie Drucker | August Bremer, Ranger Peter Brullet | 1 | 2 |
| Paul Ben-Victor | Steve Richards | Dr. Aaron Monte | 2 | 1 |
| Raymond Cruz | Raoul | Eladio Buente | 1 | 1 |
| Saxon Trainor | Officer Anne McGuire | Mary Hendershot | 2 | 1 |
| Steve Ryan | Pat Carr | Sheriff Jack Coogan | 1 | 1 |
| Steven Anderson | Bob Marks | Dr. James Parenti | 2 | 2 |
| Tamara Clatterbuck | Deena Farnham | Larina Jackson | 1 | 1 |
| Wade Williams | Arnold Struel | Raymond Pearce | 1 | 1 |
| William Lucking | Chief Sam Burns | Roky Crikenson | 1 | 1 |
| Michael David Simms | Lawyer | Senior FBI Agent | 1 | 5 |
| Joe Sabatino | Giardella's Lieutenant, Guard | Captain Al Triguero | 3 | 1 |
| David Purdham | Dr. Barkley | Dr. Lev | 1 | 2 |
| Warren Sweeney | Medical Examiner Devlin | Dr. Harriman | 2 | 3 |
| Angela Paton | Josephine Stevens | Mrs. Lukesh | 1 | 1 |
| Danny Trejo | Gabriel Mota | Cesar Ocampo | 1 | 1 |
| David Wohl | Arnie Gumble | Kenneth Ungar | 1 | 1 |
| Graham Jarvis | Mr. Galan | Dr. Austin | 1 | 1 |
| John Toles-Bey | Bernard Jenkins | John Speranza | 1 | 1 |
| Micole Mercurio | Mrs. McBride | Miss Stodie | 1 | 1 |
| Ramon Franco | Richie Morales | Nestor | 1 | 1 |
| Rob LaBelle | George Donaldson | Brad Wilczek | 1 | 1 |
| Tom Bower | Victor Ugo | Sheriff Harden | 1 | 1 |
| Zach Grenier | Rudolf Wentz | Herman Stites | 1 | 1 |
| Lawrence Pressman | Arnold Rudman | Mr. Milsap | 2 | 1 |
| Neal McDonough | Jerry Selness | Agent Robert Comer | 1 | 2 |
| Tim Halligan | Doctor | Darren Mountjoy | 2 | 1 |
| Andi Chapman | Chandra | Dr. Monique Sackheim | 1 | 1 |
| Chris Nelson Norris | David Mitchell | Edmund Peacock, S.W.A.T. Lieutenant | 1 | 2 |
| Daniel Von Bargen | Sgt. Ray Kahlins | Jacob Steven Haley | 1 | 1 |
| Gina Mastrogiacomo | Chicky | Jenny Uphouse | 1 | 1 |
| Jose Yenque | Rico | Soledad Buente | 1 | 1 |
| Miguel Sandoval | Mr. Beltran | Martin Ortega | 1 | 1 |
| Scott Hylands | Roy Sandquist | General Benjamin Bloch | 1 | 1 |
| Stanley Anderson | Professor John Goldman | Agent Lewis Schoniger | 1 | 1 |
| April Grace | Judy Foster | Danielle Manley | 1 | 1 |
| Dana Gladstone | Leo Vitale, Esq. | Dr. Landon Prince / Dale Gayhart / Harvey William Buchanon / Aaron Baker / James Dickens | 1 | 1 |
| Daniel Quinn | Gallagher | Lt. Jack Sheaffer | 1 | 1 |
| John Apicella | Councilman Paul Manos | Greg Pincus | 1 | 1 |
| Lillian Hurst | Mrs. Marquez | Flakita | 1 | 1 |
| Michael Mantell | Steve White | Dr. James Riley | 1 | 1 |
| Vic Polizos | Fire Marshall Hauser | Agent Frank Burst | 1 | 1 |
| Caroline Lagerfelt | Kitty Lear | Rustic Woman | 1 | 1 |
| Cynthia Martells | Rose Melina | District Attorney | 1 | 1 |
| Mark Bramhall | Tom | Surgical Team Member | 1 | 1 |
| Michael Rothhaar | Dr. Hulce | Dr. Couvillion | 1 | 1 |
| Annie O'Donnell | Maud Riker | Elderly Woman | 1 | 1 |
| Mik Scriba | Bartender | Lieutenant Kraskow | 1 | 1 |
| Mo Gallini | Jay Dolinky | Hood | 1 | 1 |
| Murray Rubinstein | Ernie Neiberg | Dr. Sandoz | 1 | 1 |
| Bernard White | Gerardo | Dr. Desai | 1 | 1 |
| Cynthena Sanders | Receptionist | E.R. Nurse | 1 | 1 |
| Del Zamora | Belisario | Mr. Barreiro | 1 | 1 |
| Gary Bullock | Frank Archer | Tall George | 1 | 1 |
| Jack Shearer | Seymour Gold | Judge Kinberg | 1 | 1 |
| Marty Zagon | Civilian | Landlord, Mr. Coeben | 1 | 2 |
| Maria Celedonio | Lydia Garcia | Chantara Gomez | 1 | 1 |
| Joe Basile | Officer Pulaski | Lead Guard | 1 | 1 |
| John Prosky | Frederick Converse | Medical Examiner | 1 | 1 |
| Roz Witt | Neighbor | Night Nurse | 1 | 1 |
| Ernie Lee Banks | Delmar | Maurice | 1 | 1 |
| Patricia Idlette | Civilian Assistant | Desk Clerk | 1 | 1 |
| Luis Rodriguez | Gunman | Gangbanger | 1 | 1 |
| Ralph Meyering, Jr. | Major Perkins | Surgeon | 1 | 1 |
Cast data from TVmaze, licensed CC BY-SA 4.0.