Actors in both Grey's Anatomy and Supernatural
87 actors have appeared in both Grey's Anatomy and Supernatural, across 794 episodes. The most-credited is Jeffrey Dean Morgan, Denny Duquette in Grey's Anatomy and John Winchester in Supernatural.
| Actor | In Grey's Anatomy | In Supernatural | Eps | Eps |
|---|---|---|---|---|
| Jeffrey Dean Morgan | Denny Duquette | John Winchester | 20 | 12 |
| Loretta Devine | Adele Webber | Missouri Moseley | 23 | 2 |
| Curtis Armstrong | Robert Martin | Metatron | 2 | 15 |
| Mitch Pileggi | Larry Jennings | Samuel Campbell | 9 | 8 |
| Mark Pellegrino | Chris | Lucifer, Nick | 1 | 15 |
| Sarah Drew | Dr. April Kepner | Nora | 13 | 1 |
| Yadira Guevara-Prip | Nurse Iris Santos | Dark Kaia, Kaia Nieves | 5 | 5 |
| Courtney Ford | Jill Meyer | Kelly Kline | 1 | 8 |
| Kurt Fuller | Jerry | Zachariah | 1 | 8 |
| Shoshannah Stern | Dr. Lauren Riley | Eileen Leahy | 2 | 7 |
| Danielle Savre | Lieutenant Maya Bishop | Margo Lassiter | 7 | 1 |
| Jake Abel | Tyler Moser | Adam Milligan | 1 | 5 |
| Anna Grace Barlow | Charlotte Marsh | Ashley Monroe | 1 | 2 |
| Robert Picardo | Mr. Nelligan | Wayne Whittaker | 2 | 1 |
| Robert Wisdom | Mr. Hamilton | Uriel | 1 | 4 |
| Amy Acker | Dr. Kathleen Shepherd | Andrea Barr | 1 | 1 |
| Brittany Ishibashi | Talia | Maggie Zeddmore | 1 | 1 |
| Brooke Nevin | Tricia Hale | Kat | 1 | 1 |
| Crystal Allen | Heather | Rosaleen Greenfield | 1 | 1 |
| Denis Arndt | Colonel Robbins | Father Reynolds | 1 | 1 |
Cast data from TVmaze, licensed CC BY-SA 4.0.