All 87 actors in both Grey's Anatomy and Supernatural
87 actors have appeared in both Grey's Anatomy and Supernatural, across 794 episodes. The most-credited is Jeffrey Dean Morgan, Denny Duquette in Grey's Anatomy and John Winchester in Supernatural.
| Actor | In Grey's Anatomy | In Supernatural | Eps | Eps |
|---|---|---|---|---|
| Jeffrey Dean Morgan | Denny Duquette | John Winchester | 20 | 12 |
| Loretta Devine | Adele Webber | Missouri Moseley | 23 | 2 |
| Curtis Armstrong | Robert Martin | Metatron | 2 | 15 |
| Mitch Pileggi | Larry Jennings | Samuel Campbell | 9 | 8 |
| Mark Pellegrino | Chris | Lucifer, Nick | 1 | 15 |
| Sarah Drew | Dr. April Kepner | Nora | 13 | 1 |
| Yadira Guevara-Prip | Nurse Iris Santos | Dark Kaia, Kaia Nieves | 5 | 5 |
| Courtney Ford | Jill Meyer | Kelly Kline | 1 | 8 |
| Kurt Fuller | Jerry | Zachariah | 1 | 8 |
| Shoshannah Stern | Dr. Lauren Riley | Eileen Leahy | 2 | 7 |
| Danielle Savre | Lieutenant Maya Bishop | Margo Lassiter | 7 | 1 |
| Jake Abel | Tyler Moser | Adam Milligan | 1 | 5 |
| Anna Grace Barlow | Charlotte Marsh | Ashley Monroe | 1 | 2 |
| Robert Picardo | Mr. Nelligan | Wayne Whittaker | 2 | 1 |
| Robert Wisdom | Mr. Hamilton | Uriel | 1 | 4 |
| Amy Acker | Dr. Kathleen Shepherd | Andrea Barr | 1 | 1 |
| Brittany Ishibashi | Talia | Maggie Zeddmore | 1 | 1 |
| Brooke Nevin | Tricia Hale | Kat | 1 | 1 |
| Crystal Allen | Heather | Rosaleen Greenfield | 1 | 1 |
| Denis Arndt | Colonel Robbins | Father Reynolds | 1 | 1 |
| Dylan Minnette | Ryan | Danny Carter | 1 | 1 |
| Erin Cahill | Meg Shelley | Elizabeth | 1 | 1 |
| Ever Carradine | Athena | Julia Wright | 1 | 1 |
| Jenny O'Hara | Mrs. Shelton | Julia Wilkinson | 1 | 1 |
| Jessica Steen | Dr. Rebecca Froy | Deputy Kathleen Hudak | 1 | 1 |
| Lauren Tom | Audrey Pascowitz | Linda Tran | 1 | 3 |
| Lex Medlin | Byron Gibbis | Cupid | 1 | 1 |
| Lindy Booth | Hadley | Bonnie Fuschau | 3 | 1 |
| Shannon Lucio | Amanda | April Kelly | 3 | 1 |
| Anjul Nigam | Dr. Raj Sen | Stewie Meyers | 4 | 1 |
| Brigid Brannagh | Veronica Kays | Rita Johnson | 2 | 1 |
| Gil McKinney | Chris | Henry Winchester | 1 | 2 |
| Nick D'Agosto | Dr. Graham Madden | Gavin | 2 | 1 |
| Amber Benson | Corrine Henley | Lenore | 1 | 2 |
| Amy Gumenick | Becca Wells | Young Mary Winchester | 1 | 2 |
| Ashley Crow | Linda Cotler | Mama | 1 | 1 |
| Chelan Simmons | Brenda | Jill | 1 | 1 |
| Dee Wallace | Joan Waring | Mildred Baker | 1 | 1 |
| Erin Way | Donna Woods | Michelle | 1 | 1 |
| Hal Linden | Bertram "Bertie" Hollister | Rabbi Isaac Bass | 1 | 1 |
| John Rubinstein | Keith Kalber | Charlie | 1 | 1 |
| Johnny Sneed | Garrett | Jimmy Tomorrow | 1 | 1 |
| La Monde Byrd | Martin Sterling | Robert Johnson | 1 | 1 |
| Leisha Hailey | Claire Solomon | Amelia | 1 | 1 |
| Meagen Fay | Paula | Mrs. Butters | 1 | 1 |
| Michael Weston | Quinn Durston | Young Charlie | 2 | 1 |
| Patty McCormack | Rebecca Franklin | Eleanor Holmes | 1 | 1 |
| Rick Worthy | Ray Pelletier | Alpha Vampire | 1 | 3 |
| Samantha Isler | Maya Roberts | Young Amara | 1 | 1 |
| Tiffany Dupont | Zoe | Gilda | 1 | 1 |
| Todd Stashwick | Mr. Kramer | Dracula | 1 | 1 |
| Mac Brandt | Paramedic #3 | Bucky Sims | 4 | 1 |
| Connor Price | Corban Gregory | Cyrus Styne | 2 | 1 |
| Elizabeth Bond | Kimmie Kepner | Amy Hein | 2 | 1 |
| Gabriel Tigerman | Noah Reynolds | Andy Gallagher | 1 | 2 |
| James Immekus | Andrew Langston | Del | 2 | 1 |
| Markus Flanagan | Ed Hamilton | Monroe Styne | 1 | 2 |
| Veronica Cartwright | Lydia Ashford | Lily Sunder | 2 | 1 |
| Austin Basis | Devin | Kenny Spruce | 1 | 1 |
| Eve Gordon | Mary Chapman | Joy Meyers | 1 | 1 |
| Gillian Vigman | Gillian Mendelson | Heddy | 1 | 1 |
| Helen Slater | Nadia Shelton | Susan Carter | 1 | 1 |
| Jack Conley | Jasper Hovey | Sheriff Al Britton | 1 | 1 |
| Joe Holt | Steve Beck | Sheriff Roy Dobbs | 1 | 1 |
| Kevin Brief | Barry Taylor | Reverend Buddy Boyle | 1 | 1 |
| Richard Kahan | Stuart Loeb | Gas Station Clerk | 1 | 1 |
| Rosalie Ward | Melissa Corso | Isabel Brown | 1 | 1 |
| Spencer Garrett | Jim Walker | Edward Carrigan | 1 | 1 |
| Bellamy Young | Kathy | Lucifer / Sarah | 2 | 1 |
| Brenda Bakke | Gwen Nolan | Suzie | 1 | 1 |
| Don McManus | Samuel Linden | Don Harding | 1 | 1 |
| Faran Tahir | Isaac | Osiris | 1 | 1 |
| George Coe | Ed Bullard | Pat Fremont | 1 | 1 |
| Josh Daugherty | Ken Daniels | Walter Rosen/Envy | 1 | 1 |
| Leslie Odom Jr. | PJ Walling | Guy | 1 | 1 |
| Madelyn Grace | Mary Rose Hawkins-Garrett | Angela Sullivan, Tied Up Victim | 1 | 2 |
| Sandy Sidhu | Priya | PR Agent | 1 | 1 |
| Ernie Grunwald | Gary Rubin | Sam 2 / Barnes | 1 | 1 |
| Jim Parrack | Ted Carr | Nick Monroe | 1 | 1 |
| Peter Birkenhead | Dr. Orsen | Missing Kidney Victim | 1 | 1 |
| Scott Michael Campbell | Mr. Hubble | Hank | 1 | 1 |
| Wynn Everett | Christy Cornell | Amelia Novak | 1 | 1 |
| Assaf Cohen | Aamir Elshami | Ajay | 1 | 1 |
| David Chisum | Judge Jeffrey King | President Jefferson Rooney | 1 | 1 |
| Jennifer Aspen | Elaina | Marcy Ward | 1 | 1 |
| Derek Webster | Paul Anderson | Deputy Jaffe | 1 | 1 |
| Josh Clark | Lenny Shulte | Mover | 1 | 1 |
← Grey's Anatomy × Supernatural
Cast data from TVmaze, licensed CC BY-SA 4.0.